Imaging in live, whole specimens would be a first.
Jessica is a pioneer in applying nanoparticle-based technologies to biological imaging, medical diagnostics, and research. She is a Professor of Chemical and Biomolecular Engineering at Ohio State, Associate Director of the NSF-funded Center for Emergent Materials, and Chief Science Officer of Core Quantum Technologies, a company she founded to bring a novel quantum dot based cancer diagnostic technology to the aid of cancer patients and their medical teams. Jessica has received numerous patents, awards and recognitions, and she is an indefatigable explorer, inventor, and teacher.
Jessica met fellow QSTORM PIs Peter Kner and Carol Lynn Alpert at the 2010 NSF Innovations in Biological Imaging and Visualization Ideas Lab held in rural Virginia, and the three launched the original QSTORM quest in collaboration with biologist Beth Brainerd and bioengineer Ge Yang. (see qstormlegacy.org). Jessica and Carol Lynn’s team at the Museum of Science have also collaborated on an NSF Scalable Nanomanufacturing project, sharing with public audiences the quest to speed up production of a valuable new diagnostic technology.
Q. Where are you at this point in your career?
A. I would say in the middle. I was promoted to full professor recently, but probably have another 20-30 years in the field
Q. What’s really exciting about getting this award from NSF’s IDBR (Instrument Development for Biological Research) program?
A. I am very excited to continue to work on imaging technologies. As a graduate student, I was trained under an NSF IGERT program in biomedical optics. My carrier has encompassed many things, but biological imaging continues to be the core.
Q. How does it build on what we did with the previous QSTORM project?
A. QSTORM-AO will address a critical issue identified with the (quantum dot fluorescent) probes we designed for QSTORM, namely poor signal strength. Since strength is determined by distance, we will explore methods to bring the probes closer together, and because signal strength is limited by interaction with the environment, we will try methods to better protect the probe against biological fluids.
Q. What do you hope to accomplish?
A. We hope to produce a probe that can provide more signal for a longer period of time, increasing STORM resolution.